A Modified QuEChERS Method for the Determination of Organochlorine Pesticides in Serum
Application Notes UCT-SP05:
Organochlorine (OC) pesticides are hydrocarbons with multiple chlorine substitutions. They are primarily used as insecticides. OC pesticides do not break down easily as the chlorine-carbon bonds are very strong. As such they remain in the environment long after application and bio-accumulate in organisms long after exposure. They are toxic and some are known or suspected human carcinogens, such as 4,4'-DDT, 4,4'-DDD, and the lindanes. Many OC pesticides are banned or have restricted use. These chemicals are frequently found in human body tissue, blood, fat and breast milk. This application employs a modified QuEChERS extraction and a fast, push-through cartridge clean-up for the determination of OC pesticides in human serum.
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